![]() ![]() With severe ischemia, rest pain may be persistent. Frequently, these symptoms occur at night when the legs are horizontal and improve when the legs are in a dependent position. Patients complain of rest pain or a feeling of cold or numbness in the foot and toes. This Journal feature begins with a case vignette highlighting a common clinical problem. Peripheral arterial disease, PAD, usually caused by atherosclerosis, may imply engagement of any artery outside the heart and brain, but the term is most commonly used for lower limb disorder, e.g., asymptomatic lower limb PAD, intermittent claudication (IC) and chronic limb threatening ischemia (CLTI). Peripheral artery disease (PAD) is a morbid form of atherosclerotic vascular disease that affects the lower limbs of >200 million people worldwide. In patients with severe arterial occlusive disease in whom resting blood flow cannot accommodate basal nutritional needs of the tissues, critical limb ischemia may develop. Symptoms are far more common in the lower than in the upper extremities because of the higher incidence of obstructive lesions in the former region. Abstract: Peripheral arterial disease (PAD), a relatively common manifestation of ath- erosclerotic vascular disease, is associated with significant morbidity and mortality. For example, buttock, hip, thigh, and calf discomfort occurs in patients with aortoiliac disease, whereas calf claudication develops in patients with femoral-popliteal disease. Peripheral artery disease is associated with several comorbid conditions coronary heart disease, cerebrovascular disease, or both are present in more than half the persons who receive a. The site of claudication is distal to the location of the occlusive lesion. The most common symptom is intermittent claudication, which is defined as a pain, ache, cramp, numbness, or a sense of fatigue in the muscles it occurs during exercise and is relieved by rest. Peripheral arterial disease (PAD) is a major risk factor for nonhealing foot ulcers in people with diabetes. The term can include any disorder that affects any. ![]() Fewer than 50% of patients with PAD are symptomatic, although many have a slow or impaired gait. Peripheral vascular disease, also called PVD, refers to any disease or disorder of the circulatory system outside of the brain and heart. ![]()
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